Calmetrix Biocal 2000 – Isothermal heat flow calorimeter for biological applications

Product Description

Metabolic processes usually ensure that heat is released. What could be more obvious than to consider heat as an indicator of life processes – whether in humans, animals, plants or microorganisms? As heat is so closely linked to metabolism, it indicates its changes at the moment they occur. The heat output therefore contains important information about the speed and material flows of biological conversions. These are ideal prerequisites for controlling difficult bioprocesses, such as the microbiological conversion of toxic pollutants into valuable substances. Biotechnological processes are finding their way into the pharmaceutical, agricultural and chemical industries with increasing frequency and speed. If traditional synthesis steps in the manufacture of medicines and chemical products can be replaced by biotechnological processes, production costs and environmental pollution can be reduced. This is why there is great interest in monitoring, controlling and analysing bioprocesses more precisely.

Calorimeters or biocalorimeters, which measure the heat release as a function of time and thus provide an exact picture of the metabolism of microbiological activities, are an essential tool for this. Like the larger model Calmetrix Biocal 4000 with four measuring positions, the isothermal two-channel biocalorimeter Calmetrix Biocal 2000 is used here. The biocalorimeter operates isothermally in the temperature range 5°C to 70°C, has two thermally decoupled measuring positions (no cross-talk visible), which are each coupled with a variable reference in twin design and, with a sample volume of up to 125 ml each, offers the user sufficient scope to be able to precisely analyse even less active processes in the lower microwatt range by using an appropriate sample volume. Plastic beakers with lids (disposable) or stainless steel beakers with plastic lids (sterilisable) are used as sample containers. The intuitive software is used to store the test data and a few measurement parameters. Once started, the heat development is recorded online. The measurement data thus provides both qualitative and quantitative information on the time course and extent of the reactions taking place. The respective “reference sample” consists of several metal discs, mounted on a holder, and can be quickly and variably adapted to the sample volume or its mass in terms of thermal mass.

If more measuring channels are required for a higher sample throughput and smaller sample volumes (20 ml) are sufficient or the available sample volume needs to be even larger (up to 450 ml), the isothermal multi-channel calorimeter Calmetrix I-Cal Flex can be a good alternative.

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Options and Accessories

• Plastic container (slightly conical, approx. 5 cm in diameter and approx. 5 cm in height) with lid, made of polypropylene, 125 ml capacity

• Stainless steel container (slightly conical, approx. 5 cm in diameter and approx. 5 cm in height) with plastic lid (polypropylene), 125 ml capacity; container is sterilisable

Applications